One tool in specific, a poison applicator, marks a distinct change in cultural behavior by a surge in use of organic materials. Although evidence does exist of specialized stone work dating about 75,000 years ago, those artifacts are difficult to decipher and have yet to provide a link similar to the poison applicator tools recently reanalyzed.
The abstract discussing these finds can be found at: PNAS San Material Culture
The abstract discussing these finds can be found at: PNAS San Material Culture